A state-of-the-art, multidisciplinary approach to cancer and aging

With the majority of cancers occurring in individuals over the age of 65 against a backdrop of an expanding aging population, there is an urgent need to integrate the areas of clinical oncology and geriatric care. This timely work tackles these issues head-on, presenting a truly multidisciplinary and international perspective on cancer and aging from world-renowned experts in geriatrics, oncology, behavioral science, psychology, gerontology, and public health.

Unlike other books on geriatric oncology that focus mainly on treatment,Cancer and Aging Handbook: Research and Practice examines all phases of the cancer care continuum, from prevention through evidence-based diagnosis and treatment to end-of-life care. Detailed clinical and research information helps guide readers on effective patient care as well as caregiver training, research, and intervention. Coverage includes:

Epidemiology of cancer in older adults, plus the unique physical, mental, and social issues involvedStrategies and guidelines for prevention, screening, and treatment of older individuals with cancerThe most common cancers in the elderly, including breast, colorectal, lung, prostate, and ovarian cancerCancer survivorship in older adults as well as the all-critical issues of palliative care and pain managementEmerging topics such as caregiver and family issues, different models of care, and cost considerations

An essential resource for clinicians and caregivers as well as researchers interested in this evolving field,Cancer and Aging Handbookis also useful for public health professionals and policymakers who need to formulate services and allocate resources for the growing population of older cancer patients.

Keith M. Bellizzi, Ph.D, MPH, is Assistant Professor in the Department of Human Development& Family Studies at the University of Connecticut in Storrs, Connecticut. He was trained in gerontology and epidemiology and he has spent the past several years in the Division of Cancer Control and Population Sciences at the National Cancer Institute, leading a division-wide cancer and aging initiative. Dr. Bellizzi is the current chair of the research on cancer and aging interest group of the Gerontological Society of America.  He is also a co-investigator on the Medical Health Outcomes Study and Surveillance, Epidemiology and End Results (MHOS/SEER) Program examining the impact of cancer on pre-existing medical conditions in older adults.

Margot Gosney, MD, FRCP, is Professor of Elderly Care Medicine and Director of the Institute of Health Sciences in the University of Reading, UK. She is also a clinician working in Elderly Care at the Royal Berkshire Hospital NHS Foundation Trust in Reading. Her research interests lie in the area of aging, and also include oncology, dental science for stroke patients, influenza, incontinence, falls and intellectual decline, and impaired vision and hearing. The association between nutrition and the health of elderly people has been a feature of Dr. Gosney's research and the University group has an international reputation for its findings in this area. She has published widely in peer-reviewed journals, has authored seven book chapters, and recently publishedManaging Older People in Primary Care: A Practical Guide, edited by Margot Gosney and Dr. Tess Harris; ISBN: 9780199546589; Oxford University Press, September 2009; 344pp, $67.95.

FOREWORD ix

PREFACE xi

CONTRIBUTORS xiii

PART I CANCER AND AGING IN CONTEXT

1. Epidemiology of Cancer in the Older-Aged Person 3
Lodovico Balducci

2. Biological Aspects of Aging and Cancer 13
Gabriel Tinoco, Mya Thein, and William B. Ershler

3. Physiological, Psychological, and Social Aspects of Aging 35
George A. Kuchel, Julie Robison, and Richard Fortinsky

PART II STRATEGIES FOR CANCER PREVENTION IN OLDER ADULTS

4. Overview of Cancer Prevention Strategies in Older Adults 55
Barbara K. Dunn, Peter Greenwald, and Darrell E. Anderson

5. Breast Cancer Prevention 71
Jeanne F. Noe and Hyman B. Muss

6. Colorectal Cancer Prevention and Aging 85
Ernest T. Hawk, Sherri L. Patterson, Lopa Mishra, and Kush K. Patel

7. Prostate Cancer Prevention 97
Barbara Ercole and Ian M. Thompson, Jr.

8. Lung Cancer Prevention 105
Samira Shojaee and Konstantin H. Dragnev

PART III CANCER SCREENING GUIDELINES FOR OLDER ADULTS

9. Cancer in Older People: To Screen or Not to Screen? 117
Catherine Terret and Jean-Pierre Droz

10. Breast Cancer Screening 125
Heidi D. Nelson

11. Colorectal Cancer Screening 139
Catherine Quarini

12. Prostate Cancer Screening 153
Anthony B. Miller

13. Other Screening Opportunities for the Future 163
Catherine Quarini

PART IV CANCER TREATMENT

14. General Principles in Older Adults with Cancer 175
Martine Extermann

15. Surgery for Older Adults with Cancer 183
Lynda Wyld, Malcolm Walter Ronald Reed, and Thompson Gordon Robinson

16. Chemotherapy in Older Adults with Cancer 205
Matti S. Aapro and Hans Wildiers

17. Radiotherapy in Older Adults with Cancer 221
Ian Kunkler

PART V COMMON CANCERS IN THE ELDERLY

18. Breast Cancer 243
Laura Biganzoli, Catherine Oakman, Riccardo A. Audisio, and Ian Kunkler

19. Colon Cancer 269
Demetris Papamichael and Riccardo A. Audisio

20. Lung Cancer 283
Ulrich Wedding

21. Prostate Cancer 315
Nicolas Mottet and Jean-Pierre Droz

22. Ovarian Cancer 335
Claire Falandry, Gilles Freyer, and Eric Pujade-Lauraine

PART VI CANCER SURVIVORSHIP AND AGING

23. Theoretical Perspectives from Gerontology and Lifespan Development 349
Thomas O. Blank

24. Adaptation and Adjustment to Cancer in Later Life: A Conceptual Model 365
Gary T. Deimling, Boaz Kahana, and Karen Bowman

25. Long-Term and Late Physical and Psychosocial Effects of Cancer in Older Adults 385
Kerri M. Clough-Gorr and Rebecca A. Silliman

PART VII END-OF-LIFE CARE

26. Palliative Care for Cancer Patients and Their Families 403
Cardinale Smith and Diane Meier

27. Pain Management 419
Paul Glare, Beatriz Korc-Grodzicki, Nessa Coyle, and Manpreet Boparai

PART VIII EMERGING ISSUES

28. Caregiver Knowledge and Skills 447
Paula R. Sherwood, Barbara A. Given, and Charles W. Given

29. Comprehensive Geriatric Assessment 459
Lazzaro Repetto and Angela Marie Abbatecola

30. Economic Cost of Treating Older Adults with Cancer 475
Ya-Chen Tina Shih and Benjamin D. Smith

31. Multidisciplinary Models of Care 487
Kathleen Tschantz Unroe and Harvey Jay Cohen

INDEX 499