The most up-to-date edition of a leading reference in drug disposition and pharmacokinetics

In this new, fully-revised edition ofDrug Disposition and Pharmacokinetics: Principles and Applications for Medicine, Toxicology and Biotechnology the authors deliver an authoritative and comprehensive discussion of the fate of drug molecules in the body, as well as its implications for pharmacological and clinical effects. The text offers a unique and balanced approach that combines discussion of the specific physical and biological factors affecting the absorption, distribution, metabolism, and excretion of drugs, with mathematical assessments of plasma and body fluid concentrations. The book assumes little prior knowledge and is an ideal reference for practicing professionals in industry as well as researchers and academics.

This latest edition provides readers with a new introductory chapter, as well as new chapters covering monoclonal antibodies, the role of stereochemistry in drug disposition and pharmacokinetics, DMPK in non-human species, and the recent use of AI in drug development. Readers will also find: Thorough introductions to drug disposition, pharmacokinetics, and pharmacokinetic modeling In-depth treatments of the kinetics of drug elimination and the relationship between concentration and effect, including PKPD modeling Comprehensive discussions of predictive pharmacokinetics and the disposition of biological molecules, including peptides and monoclonal antibodies Detailed examinations of the effects of sex, pregnancy, age, and disease, as well as drug monitoring in therapeutics and the use of AI in drug development and treatment

Perfect for professionals and researchers working with the scientific aspects of drug disposition in human and veterinary medicine, toxicology, and pharmacology.Drug Disposition and Pharmacokinetics will earn a place in the libraries of students of senior-level courses in pharmacy.

Stephen H. Curry, PhD, D.Sc. (Med.), has held professorial positions in Pharmacology, Physiology and Pharmaceutical Sciences at the Universities of London, Florida, and Rochester, as well as posts in the pharmaceutical industry. He is a Fellow of the Royal Pharmaceutical Society, and currently works in the field of technology transfer and translational science with a primary interest in aiding university scientists with commercialization of patented medically-significant discoveries. He is based in Rochester, New York.

Robin Whelpton, PhD, has taught undergraduate and postgraduate students of medicine, dentistry, pharmacology, analytical toxicology, pharmaceutical chemistry, and biomedical sciences at Queen Mary, University of London.

Preface

1 Setting the Scene: Concepts, Nature of Drugs and Quality of Results

2 Drug Disposition and Fate

3 Pharmacokinetic Modelling

4 Pharmacokinetics of Metabolism and Excretion

5 Quantitative Pharmacological Relationships

6 Predictive Pharmacokinetics

7 Disposition of Peptides and Other Biological Molecules

8 Monoclonal Antibodies

9 Drug Metabolism and Pharmacokinetics in Veterinary Sciences

10 Factors Affecting Plasma Concentrations. Consideration of Special Populations.

11 Pharmacogenetics, Pharmacogenomics and Precision Medicine

12 Effects of Sex and Pregnancy on Drug Disposition and Pharmacokinetics

13 Developmental Pharmacology and Age-related Phenomena

14 Effects of Disease on Drug Disposition and Pharmacokinetics

15 Role of Stereochemistry in Drug Disposition and Pharmacokinetics

16 Drug Metabolism and Pharmacokinetics in Drug Interactions and Toxicity

17 Drug Monitoring in Therapeutics

18 From Antiquity to the Age of Artificial Intelligence: Reflections on the Past, Present and Future of Drug Disposition and Pharmacokinetics

Index